Even better than Quesada on Colbert, watch the entire pilot of Mike Mignola's The Amazing Screw-On Head (video at lower right side of linked page). It starts out a little rough, but as it moves along it finds its feet. Overall it was a very funny and entertaining first episode. Hopefully we'll see a series spawn from it.
And is anyone else watching Stan Lee's Who Wants to Be a Superhero? As dopey as it is, I find myself hooked on it.